National Science Foundation- Sri Lanka

You are here: Home PROJECTS FUNDED

T cell based assay for the detection of serotype specific immunity to dengue infection and comparison of PRNT

E-mail Print PDF
Ongoing Project
Project Team: University of Sri Jayewardenapura
D051 D52 
Dr Gathsaurie Neelika Malavige
Team Leader 
Dr Chandima Jeewandara
Collaborator: National University of Singapore
D53
Prof. Ng Mah Lee
Grant No: TG/2015/Tech-D /05
Project Title: T cell based assay for the detection of serotype specific immunity to dengue infection and comparison of PRNT

Summary:
A dengue viral infection is a huge burden to developing countries including Sri Lanka. Therefore, developing a dengue vaccine is an urgent need. For dengue vaccine trials it is important to determine the previously infected dengue virus serotypes. Plaque Reduction Neutralization Assay (PRNT) is used for this purpose at present. It has been shown with studies that the validity of PRNT and use of same for dengue vaccine trials is questionable. Therefore, it is proposed to validate the already developed T cell based assay, and to compare its performance with PRNT. In order to conduct dengue vaccine trials this validation is required. Only validated T cell based assay has commercial potential. A competent team of scientists are engaged in executing validation process. There is a probability that the University can negotiate with a foreign company partner to commercialize the product.

Status:
Award on 14th August, 2015
To be completed by 13th February, 2017
Progressing well
Last Updated ( Friday, 02 October 2015 12:49 )  
Share on facebook